Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 8/20 | 0.34 |
| ▸ | DRD3 | P35462 | 8/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29135683 | 0.77 | EHMT2 (0.45) | DRD2DRD3SIGMAR1 | |
| SCHEMBL29135687 | 0.77 | EHMT2 (0.45) | DRD2DRD3SIGMAR1 | |
| SCHEMBL27756108 | 0.72 | MDM2 (0.38) | MAPT | |
| SCHEMBL27333998 | 0.71 | CHRNB4 (0.36) | MAPT | |
| SCHEMBL29978712 | 0.70 | BRD4 (0.57) | MAPTBRD4 | |
| SCHEMBL758149 | 0.70 | BRD4 (0.57) | MAPTBRD4 | |
| SCHEMBL23769078 | 0.70 | DRD2 (0.34) | DRD2DRD3CYP19A1SIGMAR1HTR1A | |
| SCHEMBL31490134 | 0.70 | DRD2 (0.34) | DRD2DRD3CYP19A1SIGMAR1HTR1A | |
| SCHEMBL23768823 | 0.69 | SCN9A (0.49) | SIRT1MAPTMAPK1 | |
| SCHEMBL31490291 | 0.69 | SCN9A (0.49) | SIRT1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379048-B | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORP | 2012-03-21 | — | — | CN | disclosed |
| CN-101379048-A | Benzo oxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-03-04 | — | — | CN | disclosed |