Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Levulinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | KDM5C | P41229 | 1/20 | 0.52 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.52 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levulinic Acid SCHEMBL113572 | 0.91 | LMNA (1.00) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL27931545 | 0.91 | LMNA (1.00) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL30530258 | 0.91 | — | — | |
| Levulinic Acid SCHEMBL20868 | 0.91 | — | — | |
| Levulinic Acid SCHEMBL21836663 | 0.88 | LMNA (0.82) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL15141274 | 0.88 | LMNA (0.82) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL1831030 | 0.88 | LMNA (0.82) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL21815732 | 0.88 | — | — | |
| Levulinic Acid SCHEMBL21815654 | 0.88 | — | — | |
| Levulinic Acid SCHEMBL1375214 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101389587-A | A process for reactive distillation of a carboxylic acid | SHELL INT RESEARCH (NL) | 2009-03-18 | — | — | CN | disclosed |