Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181294 | 0.82 | DGAT1 (0.58) | DGAT1ABL1BCRMEN1NPC1 | |
| SCHEMBL181168 | 0.81 | DGAT1 (0.81) | DGAT1 | |
| SCHEMBL181182 | 0.81 | DGAT1 (0.68) | DGAT1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL180912 | 0.80 | DGAT1 (0.62) | DGAT1ABL1BCRMEN1NPC1 | |
| SCHEMBL14617042 | 0.79 | DGAT1 (0.54) | DGAT1ABL1BCRMEN1NPC1 | |
| SCHEMBL13664084 | 0.79 | DGAT1 (0.54) | DGAT1ABL1BCRMEN1NPC1 | |
| SCHEMBL15445166 | 0.79 | DGAT1 (0.54) | DGAT1ABL1BCRMEN1NPC1 | |
| SCHEMBL180688 | 0.79 | DGAT1 (0.54) | DGAT1ABL1BCRMEN1NPC1 | |
| SCHEMBL13664085 | 0.77 | DGAT1 (0.53) | DGAT1ABL1BCRMEN1NPC1 | |
| SCHEMBL30385270 | 0.77 | DGAT1 (0.53) | DGAT1ABL1BCRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103086981-A | New compounds | NOVARTIS AG | 2013-05-08 | — | — | CN | claimed |
| CN-101415683-A | Novel compounds | NOVARTIS AG (CH) | 2009-04-22 | — | — | CN | claimed |
| CN-103288721-A | (4-(4-[6-(trifluoromethyl-pyridin-3-ylamino)-n-containing-heteroaryl]-phenyl)-cyclohexyl)-acetic acid derivatives and pharmaceutical uses thereof | NOVARTIS AG | 2013-09-11 | — | — | CN | disclosed |
| CN-101415683-B | Novel compounds | NOVARTIS AG | 2013-07-17 | — | — | CN | disclosed |
| CN-103086981-A | New compounds | NOVARTIS AG | 2013-05-08 | — | — | CN | disclosed |
| CN-101415683-A | Novel compounds | NOVARTIS AG (CH) | 2009-04-22 | — | — | CN | disclosed |