Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.63 |
| ▸ | SIRT7 | Q9NRC8 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 8/20 | 0.42 |
| ▸ | FLT1 | P17948 | 7/20 | 0.42 |
| ▸ | FLT4 | P35916 | 7/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180759 | 0.85 | DGAT1 (0.70) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL180635 | 0.81 | DGAT1 (0.58) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL180813 | 0.81 | DGAT1 (0.79) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL181174 | 0.80 | DGAT1 (0.77) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL180683 | 0.79 | DGAT1 (0.70) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL180970 | 0.78 | DGAT1 (0.65) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL180428 | 0.77 | DGAT1 (1.00) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL180799 | 0.77 | DGAT1 (0.72) | DGAT1SIRT7VCPKDRFLT1 | |
| SCHEMBL27488925 | 0.74 | PPARG (0.46) | LMNAMAPTHTTNPSR1 | |
| Tert-Butyl Formate SCHEMBL27737391 | 0.72 | DGAT1 (0.49) | DGAT1SIRT7VCPKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103288721-A | (4-(4-[6-(trifluoromethyl-pyridin-3-ylamino)-n-containing-heteroaryl]-phenyl)-cyclohexyl)-acetic acid derivatives and pharmaceutical uses thereof | NOVARTIS AG | 2013-09-11 | — | — | CN | disclosed |
| CN-101415683-B | Novel compounds | NOVARTIS AG | 2013-07-17 | — | — | CN | disclosed |
| CN-103086981-A | New compounds | NOVARTIS AG | 2013-05-08 | — | — | CN | disclosed |
| CN-101415683-A | Novel compounds | NOVARTIS AG (CH) | 2009-04-22 | — | — | CN | disclosed |