Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 13/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LIFR | P42702 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770346 | 0.94 | NR1H4 (0.60) | NR1H4MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL2773791 | 0.92 | NR1H4 (0.59) | NR1H4MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL2771180 | 0.91 | NR1H4 (0.63) | NR1H4MRGPRX4TP53PKMNFKB1 | |
| SCHEMBL2773887 | 0.87 | NR1H4 (0.61) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2773707 | 0.84 | NR1H4 (0.60) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2770195 | 0.84 | NR1H4 (0.59) | NR1H4MRGPRX4 | |
| SCHEMBL2771664 | 0.83 | NR1H4 (0.54) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2772150 | 0.82 | MRGPRX4 (0.52) | NR1H4MRGPRX4 | |
| SCHEMBL2772217 | 0.82 | NR1H4 (0.57) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2769708 | 0.82 | NR1H4 (0.51) | NR1H4MRGPRX4TP53PKMNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |