Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.61 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.47 |
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | LIFR | P42702 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772217 | 0.93 | NR1H4 (0.57) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2771180 | 0.93 | NR1H4 (0.63) | NR1H4MRGPRX4BCL2MCL1LIFR | |
| SCHEMBL2773371 | 0.90 | NR1H4 (0.58) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2770887 | 0.88 | NR1H4 (0.56) | NR1H4MRGPRX4 | |
| SCHEMBL2771218 | 0.88 | NR1H4 (0.51) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2773436 | 0.88 | NR1H4 (0.55) | NR1H4MRGPRX4BCL2MCL1CYP3A4 | |
| SCHEMBL2773707 | 0.88 | NR1H4 (0.60) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2773808 | 0.87 | NR1H4 (0.58) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2770346 | 0.87 | NR1H4 (0.60) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2770195 | 0.87 | NR1H4 (0.59) | NR1H4MRGPRX4BCL2MCL1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |