SCHEMBL27738375

SCHEMBL27738375

O=C1CCC(CNC2CCC2)N1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 14/20 0.34
PDCD1LG2 Q9BQ51 9/20 0.34
PDCD1 Q15116 5/20 0.34
TACR1 P25103 3/20 0.34
KCNA5 P22460 1/20 0.33
CTSD P07339 1/20 0.33
MAN1B1 Q9UKM7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1776966 1.00 CD274 (0.34) CD274PDCD1LG2PDCD1TACR1KCNA5
SCHEMBL1777640 0.96 MAN1B1 (0.35) CD274PDCD1LG2PDCD1TACR1KCNA5
SCHEMBL27738376 0.96 MAN1B1 (0.35) CD274PDCD1LG2PDCD1TACR1KCNA5
SCHEMBL27738350 0.95 DPP7 (0.37) CD274PDCD1LG2PDCD1TACR1KCNA5
SCHEMBL1777255 0.95 DPP7 (0.37) CD274PDCD1LG2PDCD1TACR1KCNA5
SCHEMBL21309877 0.76
SCHEMBL21309879 0.76
SCHEMBL13519035 0.76 ADH1B (0.39) CD274PDCD1LG2PDCD1
SCHEMBL2570636 0.76 ADH1B (0.39) CD274PDCD1LG2PDCD1
SCHEMBL2568388 0.76 ADH1B (0.39) CD274PDCD1LG2PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101296902-A Compounds comprising lactam or lactam derivative moieties, processes for preparing them and their use UCB PHARMA SA (BE) 2008-10-29 CN claimed
CN-101296902-A Compounds comprising lactam or lactam derivative moieties, processes for preparing them and their use UCB PHARMA SA (BE) 2008-10-29 CN disclosed