Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.64 |
| ▸ | CDC7 | O00311 | 12/20 | 0.60 |
| ▸ | CDK1 | P06493 | 3/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 3/20 | 0.60 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.60 |
| ▸ | CDK9 | P50750 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.60 |
| ▸ | PRKCB | P05771 | 1/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185880 | 0.92 | JAK2 (0.77) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27851407 | 0.87 | JAK2 (0.84) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL27938063 | 0.86 | JAK2 (0.82) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27759277 | 0.85 | JAK2 (0.64) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL28779559 | 0.85 | JAK2 (0.64) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL28779558 | 0.85 | JAK2 (0.84) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27738496 | 0.85 | CDC7 (0.79) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27738547 | 0.84 | CDC7 (0.83) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL27833178 | 0.84 | JAK2 (0.82) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL27851387 | 0.84 | CDC7 (0.77) | JAK2CDC7CDK1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410387-B | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furan-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2013-12-18 | — | — | CN | disclosed |
| CN-101410387-A | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furan-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-04-15 | — | — | CN | disclosed |