Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18102201 | 0.80 | ALDH1A1 (0.60) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL11983452 | 0.80 | ALDH1A1 (0.60) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL24989822 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL28605468 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL10460589 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL21384157 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL11929541 | 0.75 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL9609775 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL14038147 | 0.75 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTPOLBCYP1A2 | |
| SCHEMBL15046551 | 0.74 | KDM4E (0.53) | KDM4EALDH1A1MAPTPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101287738-B | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | disclosed |
| CN-101287738-A | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2008-10-15 | — | — | CN | disclosed |