Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.54 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 3/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | BLVRB | P30043 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772857 | 0.89 | NR1H4 (0.55) | NR1H4TARBP2RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2771135 | 0.82 | NR1H4 (0.57) | NR1H4RAB9ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL2771697 | 0.77 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL2773254 | 0.76 | NR1H4 (0.52) | NR1H4 | |
| SCHEMBL2771465 | 0.76 | NR1H4 (0.64) | NR1H4RAB9ANPC1PPARD | |
| SCHEMBL2774467 | 0.76 | NR1H4 (0.57) | NR1H4 | |
| SCHEMBL2773870 | 0.76 | NR1H4 (0.55) | NR1H4PPARD | |
| SCHEMBL2773272 | 0.76 | NR1H4 (0.57) | NR1H4 | |
| SCHEMBL2770414 | 0.76 | NR1H4 (0.57) | NR1H4RAB9ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL2771659 | 0.76 | NR1H4 (0.61) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |