Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.55 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774019 | 0.89 | NR1H4 (0.54) | NR1H4TARBP2SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL2770414 | 0.85 | NR1H4 (0.57) | NR1H4MRGPRX4SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL2770495 | 0.84 | NR1H4 (0.67) | NR1H4MRGPRX4VDR | |
| SCHEMBL2770807 | 0.84 | NR1H4 (0.58) | NR1H4MRGPRX4VDR | |
| SCHEMBL2773539 | 0.83 | NR1H4 (0.54) | NR1H4MRGPRX4VDR | |
| SCHEMBL2771697 | 0.83 | NR1H4 (0.63) | NR1H4MRGPRX4VDR | |
| SCHEMBL2770454 | 0.82 | NR1H4 (0.59) | NR1H4MRGPRX4VDR | |
| SCHEMBL2772894 | 0.82 | NR1H4 (0.67) | NR1H4MRGPRX4 | |
| SCHEMBL2772951 | 0.82 | NR1H4 (0.37) | NR1H4TARBP2NPSR1RXFP1PPARD | |
| SCHEMBL2770415 | 0.82 | NR1H4 (0.54) | NR1H4MRGPRX4VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |