Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277025 | 0.91 | MDM4 (0.43) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL274462 | 0.91 | MDM4 (0.43) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL274463 | 0.91 | MDM4 (0.43) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL699152 | 0.88 | APP (0.57) | APPMAPTSNCABCHEALDH1A1 | |
| SCHEMBL4766463 | 0.87 | MDM4 (0.41) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL13929141 | 0.87 | MDM4 (0.41) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL275409 | 0.87 | PPARG (0.50) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL279251 | 0.87 | PPARG (0.50) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL275408 | 0.87 | PPARG (0.50) | MDM4TP53MDM2APPMAPT | |
| SCHEMBL27740826 | 0.87 | PPARG (0.48) | MDM4TP53MDM2APPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101400680-A | Spiroindolinone derivatives | HOFFMANN LA ROCHE (CH) | 2009-04-01 | — | — | CN | disclosed |
| CN-101400679-A | Spiroindolinone derivatives | HOFFMANN LA ROCHE (CH) | 2009-04-01 | — | — | CN | disclosed |