Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | SNCA | P37840 | 7/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27740824 | 0.88 | MDM4 (0.51) | APPMAPTSNCABCHEALDH1A1 | |
| SCHEMBL699531 | 0.86 | MAPT (0.43) | APPMAPTSNCABCHENFKB1 | |
| SCHEMBL28266654 | 0.82 | BCHE (0.47) | APPMAPTSNCABCHEALDH1A1 | |
| SCHEMBL28266653 | 0.82 | BCHE (0.47) | APPMAPTSNCABCHEALDH1A1 | |
| SCHEMBL28706911 | 0.81 | ALDH1A1 (0.60) | APPMAPTSNCAALDH1A1ERBB2 | |
| SCHEMBL28706915 | 0.81 | ALDH1A1 (0.60) | APPMAPTSNCAALDH1A1ERBB2 | |
| SCHEMBL27743821 | 0.81 | APP (0.44) | APPMAPTSNCABCHEALDH1A1 | |
| SCHEMBL13144372 | 0.79 | CES1 (0.61) | APPMAPTSNCABCHEALDH1A1 | |
| SCHEMBL277025 | 0.79 | MDM4 (0.43) | APPMAPTSNCABCHENFKB1 | |
| SCHEMBL274463 | 0.79 | MDM4 (0.43) | APPMAPTSNCABCHENFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421866-A1 | 3,3'-SPIROINDOLINONE DERIVATIVES AND THEIR USE FOR CANCER | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121995-A1 | 3,3'-SPIROINDOLINONE DERIVATIVES AND THEIR USE FOR CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |