SCHEMBL27744372

SCHEMBL27744372

CC(C)(C)OC(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)Nc1ccc(-c2ccncc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 2/20 0.53
CTSS P25774 6/20 0.50
CTSK P43235 5/20 0.50
HDAC8 Q9BY41 1/20 0.49
PPARG P37231 1/20 0.48
PPARA Q07869 1/20 0.48
USP30 Q70CQ3 1/20 0.45
BCL2 P10415 4/20 0.45
MCL1 Q07820 1/20 0.45
MMP1 P03956 1/20 0.43
MMP2 P08253 1/20 0.43
MMP9 P14780 1/20 0.43
MMP8 P22894 1/20 0.43
MMP13 P45452 1/20 0.43
CTSL P07711 1/20 0.43
CTSB P07858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5163314 0.91 CTSS (0.60) CTSSCTSKHDAC8PPARGPPARA
SCHEMBL6409791 0.91 CTSS (0.60) CTSSCTSKHDAC8PPARGPPARA
SCHEMBL27744402 0.86 CTSS (0.59) CYP17A1CTSSCTSKHDAC8USP30
SCHEMBL27723742 0.86 CYP17A1 (0.56) CYP17A1CTSSCTSKHDAC8PPARG
SCHEMBL27723748 0.86 CTSS (0.59) CYP17A1CTSSCTSKHDAC8USP30
SCHEMBL3008254 0.86 HDAC8 (0.59) CTSSCTSKHDAC8PPARGPPARA
SCHEMBL6803446 0.86 HDAC8 (0.64) CTSSCTSKHDAC8PPARGPPARA
SCHEMBL6803437 0.86 HDAC8 (0.64) CTSSCTSKHDAC8PPARGPPARA
SCHEMBL3008259 0.86 HDAC8 (0.59) CTSSCTSKHDAC8PPARGPPARA
SCHEMBL18474966 0.85 PPARG (0.55) CTSSCTSKHDAC8PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101253152-A Amide derivatives as ROCK inhibitors ASTELLAS PHARMA INC (JP) 2008-08-27 CN disclosed