Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.56 |
| ▸ | MLYCD | O95822 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765848 | 0.85 | MAPK14 (0.63) | MAPK14MLYCDMAPK9MAPK10MAPK11 | |
| SCHEMBL4335666 | 0.83 | MAPK14 (0.59) | MAPK14MLYCDHSP90AA1MAPK9MAPK10 | |
| SCHEMBL27765856 | 0.82 | MAPK14 (0.63) | MAPK14MLYCDMAPK9MAPK10MAPK11 | |
| SCHEMBL4340388 | 0.82 | MAPK14 (0.66) | MAPK14MLYCDHSP90AA1MAPK9MAPK10 | |
| SCHEMBL4329365 | 0.79 | MAPK14 (0.66) | MAPK14MLYCDHSP90AA1MAPK9MAPK10 | |
| SCHEMBL27765845 | 0.78 | MAPK14 (0.68) | MAPK14MLYCDMAPK9MAPK10MAPK11 | |
| SCHEMBL4336972 | 0.78 | MAPK14 (0.63) | MAPK14MLYCDHSP90AA1MAPK9MAPK10 | |
| SCHEMBL2038477 | 0.77 | P2RX7 (0.45) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL27744921 | 0.76 | MAPK14 (0.55) | MAPK14MLYCDMAPK9MAPK10MAPK11 | |
| SCHEMBL27765828 | 0.75 | MAPK14 (0.52) | MAPK14MLYCDHSP90AA1MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101472921-B | Pyridylisoxazole derivative | ASKA PHARM CO LTD | 2012-10-10 | — | — | CN | disclosed |
| CN-101472921-A | Pyridylisoxazole derivative | ASKA PHARM CO LTD (JP) | 2009-07-01 | — | — | CN | disclosed |