Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 6/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27744978 | 1.00 | BRAF (0.36) | BRAFCDK7SYKITKPIM3 | |
| SCHEMBL2934019 | 0.78 | BRAF (0.47) | BRAFSYKITKGSK3B | |
| Acetic Acid SCHEMBL2933253 | 0.76 | BRAF (0.47) | BRAFSYKITK | |
| SCHEMBL2933256 | 0.76 | BRAF (0.57) | BRAFITK | |
| SCHEMBL2932836 | 0.75 | ITK (0.41) | BRAFITKKDR | |
| SCHEMBL2929169 | 0.73 | ATR (0.47) | SYKCDK2KDR | |
| SCHEMBL2930294 | 0.73 | ATR (0.47) | SYKCDK2KDR | |
| SCHEMBL2928571 | 0.73 | BTK (0.53) | BRAFROCK2 | |
| SCHEMBL27759874 | 0.73 | — | — | |
| Acetic Acid SCHEMBL2934985 | 0.72 | BTK (0.52) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101472912-A | Pyridine and pyrazine derivatives as MNK kinase inhibitors | BIOVITRUM AB PUBL (SE) | 2009-07-01 | — | — | CN | claimed |
| CN-101472912-A | Pyridine and pyrazine derivatives as MNK kinase inhibitors | BIOVITRUM AB PUBL (SE) | 2009-07-01 | — | — | CN | disclosed |