Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 4/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.41 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934019 | 0.83 | BRAF (0.47) | ITKBRAF | |
| Acetic Acid SCHEMBL2933253 | 0.82 | BRAF (0.47) | ITKEGFRPIK3CABRAF | |
| SCHEMBL2933256 | 0.79 | BRAF (0.57) | ITKBRAF | |
| SCHEMBL2927043 | 0.76 | HCAR3 (0.48) | ITKBRAF | |
| SCHEMBL2928571 | 0.76 | BTK (0.53) | PIK3CABRAFBTKRAB9ASMN1; SMN2 | |
| SCHEMBL2931626 | 0.76 | BRAF (0.39) | ITKBRAFKDR | |
| SCHEMBL2928708 | 0.76 | BRAF (0.39) | ITKBRAFKDR | |
| Acetic Acid SCHEMBL2934985 | 0.75 | BTK (0.52) | PIK3CABRAFBTKRAB9ASMN1; SMN2 | |
| SCHEMBL27744978 | 0.75 | BRAF (0.36) | ITKBRAFKDR | |
| SCHEMBL27745009 | 0.75 | BRAF (0.36) | ITKBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | claimed |