SCHEMBL277454

SCHEMBL277454

CC(C)(C)c1ccc(C=C(Cl)Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.48
LMNA P02545 1/20 0.46
TYR P14679 1/20 0.46
GRIN2D O15399 2/20 0.44
GRIN3B O60391 2/20 0.44
GRIN1 Q05586 2/20 0.44
GRIN2A Q12879 2/20 0.44
GRIN2B Q13224 2/20 0.44
GRIN2C Q14957 2/20 0.44
GRIN3A Q8TCU5 2/20 0.44
TSHR P16473 1/20 0.42
ALDH1A1 P00352 4/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
MAPT P10636 3/20 0.41
RAB9A P51151 3/20 0.41
NPC1 O15118 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
KDM4E B2RXH2 1/20 0.41
AMY1A P0DUB6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28361211 0.79 CYP1A2 (0.43) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL9637976 0.79 CYP1A2 (0.50) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL27919065 0.78 CYP1A2 (0.50) CYP1A2LMNATYRALDH1A1MEN1
SCHEMBL31474575 0.77 CYP1A2 (0.48) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL17285553 0.77 CYP1A2 (0.48) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL10574212 0.75 CYP1A2 (0.43) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL10574216 0.75 CYP1A2 (0.43) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL31124864 0.74 GRIN2D (0.46) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL7923836 0.74 CYP1A2 (0.46) CYP1A2LMNATYRGRIN2DGRIN3B
SCHEMBL18601374 0.73 CYP1A2 (0.48) CYP1A2LMNATYRGRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4732464-B2 2011-07-27 JP claimed
EP-2255228-A1 LENSES COMPRISING AMPHIPHILIC MULTIBLOCK COPOLYMERS Bausch & Lomb Incorporated (US) 2010-12-01 EP claimed
US-20100069522-A1 LENSES COMPRISING AMPHIPHILIC MULTIBLOCK COPOLYMERS HUMAX PHARMACEUTICAL S.A. (CO) 2010-03-18 US claimed
EP-1828813-B1 POLYMERIZABLE SURFACTANTS AND THEIR USE AS DEVICE FORMING COMONOMERS BAUSCH & LOMB (US) 2010-02-10 EP claimed
WO-2009117374-A1 LENSES COMPRISING AMPHIPHILIC MULTIBLOCK COPOLYMERS BAUSCH & LOMB INCORPORATED (US) 2009-09-24 WO claimed
WO-2008057104-A1 USE OF THERMAL REVERSIBLE ASSOCIATIONS FOR ENHANCED POLYMER INTERACTIONS BAUSCH & LOMB INCORPORATED (US) 2008-05-15 WO claimed
WO-2007149083-A1 POLYMERIZABLE SURFACTANTS AND THEIR USE AS DEVICE FORMING COMONOMERS BAUSCH & LOMB INCORPORATED (US) 2007-12-27 WO claimed
EP-1828813-A1 POLYMERIZABLE SURFACTANTS AND THEIR USE AS DEVICE FORMING COMONOMERS Bausch & Lomb Incorporated (US) 2007-09-05 EP claimed
US-20070123602-A1 Use of thermal reversible associations for enhanced polymer interactions BAUSCH & LOMB INCORPORATED 2007-05-31 US claimed
US-20060275342-A1 Polymerizable surfactants and their use as device forming comonomers BAUSCH & LOMB INCORPORATED 2006-12-07 US claimed
US-5364918-A Surface modification of polymer objects BAUSCH & LOMB INCORPORATED (US) 1994-11-15 US claimed
EP-0559820-A1 SURFACE COATING OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1993-09-15 EP claimed
EP-0559784-A1 SURFACE-ACTIVE MACROMONOMERS. BAUSCH & LOMB (US) 1993-09-15 EP claimed
EP-0559809-A1 SURFACE MODIFICATION OF POLYMER OBJECTS. BAUSCH & LOMB (US) 1993-09-15 EP claimed
US-5219965-A Adding polymerizable surfactant to monomer mixture; contact lenses BAUSCH & LOMB INCORPORATED (US) 1993-06-15 US claimed
US-5177165-A Contact lenses BAUSCH & LOMB INCORPORATED (US) 1993-01-05 US claimed
US-5135297-A Immersing a contact lens in an aqueous dispersion of a polymerizable surfactant macromer, a crosslinker and a free radical catalyst and irradiating with UV light; wetting agents BAUSCH & LOMB INCORPORATED (US) 1992-08-04 US claimed
WO-1992009639-A2 SURFACE-ACTIVE MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO claimed
WO-1992009650-A1 SURFACE COATING OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO claimed
WO-1992009644-A1 SURFACE MODIFICATION OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO claimed