Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 5/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27725074 | 0.89 | HDAC3 (0.41) | HDAC3HDAC1HDAC6DHODHCDC7 | |
| SCHEMBL27748447 | 0.87 | KCNH2 (0.37) | HDAC3HDAC1HDAC6DHODHF2RL1 | |
| SCHEMBL19259491 | 0.79 | HDAC3 (0.43) | HDAC3HDAC1HDAC6DHODHCDC7 | |
| SCHEMBL27727426 | 0.76 | KCNH2 (0.37) | HDAC3HDAC1HDAC6DHODHF2RL1 | |
| SCHEMBL27745887 | 0.76 | HDAC3 (0.40) | HDAC3HDAC1HDAC6CDC7DBF4 | |
| SCHEMBL27725072 | 0.74 | CDC7 (0.47) | HDAC3HDAC1HDAC6CDC7DBF4 | |
| SCHEMBL405716 | 0.73 | EIF4E (0.44) | HDAC3HDAC1HDAC6EIF4EF2RL1 | |
| SCHEMBL16237487 | 0.72 | HDAC3 (0.43) | HDAC3HDAC1HDAC6DHODHCDC7 | |
| SCHEMBL15515454 | 0.70 | CDC7 (0.43) | HDAC3HDAC1HDAC6DHODHCDC7 | |
| SCHEMBL27690481 | 0.69 | EIF4E (0.42) | DHODHCDC7DBF4EIF4EP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101328170-B | Fluorophenyl-substituted thiazole dihydropyrimidine | ZHANG ZHONGNENG | 2011-09-14 | — | — | CN | disclosed |
| CN-101328168-B | Diethylcarbamyl-substituted thiazole dihydropyrimidine | ZHANG ZHONGNENG | 2011-09-07 | — | — | CN | disclosed |
| CN-101328168-A | Diethylcarbamyl-substituted thiazole dihydropyrimidine | ZHANG ZHONGNENG (CN) | 2008-12-24 | — | — | CN | disclosed |
| CN-101328170-A | Fluorophenyl-substituted thiazole dihydropyrimidine | ZHANG ZHONGNENG (CN) | 2008-12-24 | — | — | CN | disclosed |