Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27758388 | 0.89 | IGF1R (0.40) | IGF1RALOX15OPRK1ADRB2ADORA3 | |
| SCHEMBL27725116 | 0.88 | PTPN1 (0.37) | PTPN1S1PR1 | |
| SCHEMBL27725115 | 0.87 | GRIN2D (0.42) | PTPN1 | |
| SCHEMBL27758479 | 0.87 | IGF1R (0.43) | IGF1RALOX15OPRK1ADRB2ADORA3 | |
| SCHEMBL27745967 | 0.86 | PTPN1 (0.36) | PTPN1CYP1A2SLC6A2SLC6A3 | |
| SCHEMBL27760075 | 0.85 | PTPN1 (0.48) | PTPN1IGF1RALOX15CYP1A2SLC6A2 | |
| SCHEMBL27745954 | 0.85 | PTPN1 (0.38) | PTPN1 | |
| SCHEMBL27725129 | 0.85 | PTPN1 (0.40) | PTPN1CYP1A2 | |
| SCHEMBL27760131 | 0.84 | ADRB2 (0.36) | PTPN1IGF1RALOX15OPRK1ADRB2 | |
| SCHEMBL27781668 | 0.84 | PTPN1 (0.39) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101326173-A | Thiadiazoles derivant as anti-diabetes agent | NOVARTIS AG (CH) | 2008-12-17 | — | — | CN | claimed |
| CN-101883579-A | Combination of protein tyrosine phosphatase inhibitors and human growth hormone for the treatment of muscle atrophy and related disorders | NOVARTIS AG | 2010-11-10 | — | — | CN | disclosed |
| CN-101547694-A | Protein tyrosine phosphatase inhibitors for promoting physiological cardiac hypertrophy | NOVARTIS AG (CH) | 2009-09-30 | — | — | CN | disclosed |
| CN-101326173-A | Thiadiazoles derivant as anti-diabetes agent | NOVARTIS AG (CH) | 2008-12-17 | — | — | CN | disclosed |