Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.41 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28041672 | 0.92 | HIF1A (0.38) | CYP2C19HIF1AALDH1A1KDM4ELMNA | |
| SCHEMBL435821 | 0.85 | ELANE (0.45) | CYP2C19HIF1AALDH1A1KDM4EMEN1 | |
| Phosphine SCHEMBL27261108 | 0.83 | ELANE (0.44) | CYP2C19HIF1AALDH1A1KDM4EMEN1 | |
| Bicarbonate SCHEMBL27420408 | 0.83 | ELANE (0.44) | CYP2C19HIF1AALDH1A1KDM4EMEN1 | |
| Acetic Acid SCHEMBL28277118 | 0.83 | ELANE (0.44) | CYP2C19HIF1AALDH1A1KDM4EMEN1 | |
| SCHEMBL27800485 | 0.83 | CYP2C19 (0.36) | CYP2C19HIF1AALDH1A1KDM4ELMNA | |
| SCHEMBL28845220 | 0.82 | ELANE (0.42) | CYP2C19HIF1AALDH1A1KDM4EMEN1 | |
| Methacrylic Acid SCHEMBL27752618 | 0.82 | ELANE (0.42) | CYP2C19HIF1AALDH1A1KDM4EMEN1 | |
| Glycerin SCHEMBL28197442 | 0.81 | CYP1A2 (0.39) | CYP2C19HIF1AALDH1A1KDM4ELMNA | |
| SCHEMBL7607192 | 0.81 | ALDH1A1 (0.48) | CYP2C19HIF1AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103044719-B | A kind of have thermoplastic starch plastic of high hydrophobicity energy and preparation method thereof | SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) | 2015-09-16 | — | — | CN | claimed |
| CN-103044719-A | Thermoplastic starch plastic with high hydrophobic property and preparation method thereof | UNIV SOUTH CHINA TECH | 2013-04-17 | — | — | CN | claimed |
| CN-107428857-A | Heat-expandable microsphere and application thereof | 松本油脂制药株式会社 | 2017-12-01 | — | — | CN | disclosed |
| CN-103044719-B | A kind of have thermoplastic starch plastic of high hydrophobicity energy and preparation method thereof | SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) | 2015-09-16 | — | — | CN | disclosed |
| CN-102585485-B | Starch/thermoplastic polyurethane (TPU) composite material with high mechanical property and preparation method thereof | UNIV SOUTH CHINA TECH | 2014-04-02 | — | — | CN | disclosed |
| CN-103238103-A | Liquid crystal display device | KONICA MINOLTA OPTO INC | 2013-08-07 | — | — | CN | disclosed |
| CN-103044719-A | Thermoplastic starch plastic with high hydrophobic property and preparation method thereof | UNIV SOUTH CHINA TECH | 2013-04-17 | — | — | CN | disclosed |
| CN-101473254-B | Polarizing plate protective film, polarizing plate, and liquid crystal display device | KONICA MINOLTA OPTO INC | 2011-06-15 | — | — | CN | disclosed |
| CN-102015248-A | Process for producing optical film, optical film, polarizer, and liquid-crystal display | KONICA MINOLTA OPTO INC | 2011-04-13 | — | — | CN | disclosed |
| CN-101679900-A | Lubricating composition comprising an ashless antiwear agent based on a hydroxypolycarboxylic acid derivative and a molybdenum compound | LUBRIZOL CORP | 2010-03-24 | — | — | CN | disclosed |
| CN-101473254-A | Polarizing plate protective film, polarizing plate, and liquid crystal display device | KONICA MINOLTA OPTO INC (JP) | 2009-07-01 | — | — | CN | disclosed |