Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.64 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CDC42 | P60953 | 1/20 | 0.64 |
| ▸ | RAC1 | P63000 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246306 | 1.00 | TDP1 (0.68) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9289868 | 0.93 | PTGS2 (0.66) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9239307 | 0.93 | PTGS2 (0.66) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL13109330 | 0.92 | PTGS2 (0.62) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| Hno SCHEMBL31072088 | 0.91 | PTGS2 (0.63) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL13089018 | 0.91 | PTGS2 (0.63) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL13592731 | 0.90 | TDP1 (0.69) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9243075 | 0.89 | PTGS2 (0.62) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL11718787 | 0.89 | PTGS2 (0.62) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL10733997 | 0.89 | PTGS2 (0.62) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101486643-B | Trans naproxen ester, optical isomer thereof, as well as preparation and use thereof | UNIV HUNAN | 2012-08-15 | — | — | CN | disclosed |
| CN-101486643-A | Trans naproxen ester, optical isomer thereof, as well as preparation and use thereof | UNIV HUNAN (CN) | 2009-07-22 | — | — | CN | disclosed |