Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 8/20 | 0.70 |
| ▸ | MERTK | Q12866 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL27747125 | 0.95 | ACVRL1 (0.63) | ACVRL1MERTKFLT3KDRKIT | |
| SCHEMBL58954 | 0.91 | ACVRL1 (0.64) | ACVRL1MERTKFLT3KDRKIT | |
| SCHEMBL58056 | 0.86 | ACVRL1 (0.61) | ACVRL1MERTKFLT3KDRKIT | |
| Hydrochloric Acid SCHEMBL27768114 | 0.86 | ACVRL1 (0.63) | ACVRL1MERTKFLT3KDRKIT | |
| Trifluoroacetic Acid SCHEMBL841675 | 0.86 | ACVRL1 (0.58) | ACVRL1MERTKFLT3KDRKIT | |
| SCHEMBL59783 | 0.85 | ACVRL1 (0.66) | ACVRL1MERTKFLT3KDRKIT | |
| SCHEMBL59333 | 0.85 | ACVRL1 (0.62) | ACVRL1MERTKFLT3KDRKIT | |
| SCHEMBL59916 | 0.85 | ACVRL1 (0.66) | ACVRL1MERTKFLT3KDRKIT | |
| SCHEMBL65790 | 0.84 | ACVRL1 (0.63) | ACVRL1MERTKFLT3KDRKIT | |
| SCHEMBL878975 | 0.83 | ACVRL1 (0.63) | ACVRL1MERTKFLT3KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |