Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.47 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768306 | 0.90 | IKBKB (0.39) | CHEK1IKBKBMAPTKDM4EMEN1 | |
| SCHEMBL27747338 | 0.90 | CHEK1 (0.37) | CHEK1MAPTPOLBKDM4EMEN1 | |
| SCHEMBL28776699 | 0.82 | CHEK1 (0.34) | CHEK1ALDH1A1MAPTPOLBKDM4E | |
| SCHEMBL12922001 | 0.79 | CHEK1 (0.48) | CHEK1IKBKBMAP3K8STK17B | |
| SCHEMBL8827896 | 0.78 | CHEK1 (0.47) | CHEK1IKBKBALDH1A1MAPTPOLB | |
| SCHEMBL14997868 | 0.77 | CHEK1 (0.45) | CHEK1IKBKBALDH1A1MAPTPOLB | |
| SCHEMBL12922023 | 0.76 | CHEK1 (0.57) | CHEK1IKBKBALDH1A1MAPTKDM4E | |
| SCHEMBL29900031 | 0.76 | CHEK1 (0.46) | CHEK1IKBKBALDH1A1KDM4E | |
| SCHEMBL12921998 | 0.76 | CHEK1 (0.46) | CHEK1IKBKBALDH1A1KDM4E | |
| SCHEMBL12922015 | 0.76 | CHEK1 (0.56) | CHEK1IKBKBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | claimed |
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | disclosed |