Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27747338 | 0.90 | CHEK1 (0.37) | CYP1A2CYP2C9CYP2C19CHEK1JAK2 | |
| SCHEMBL27747341 | 0.90 | CHEK1 (0.47) | IKBKBCHEK1MEN1KMT2AKDM4E | |
| SCHEMBL8834591 | 0.78 | IKBKB (0.39) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5237983 | 0.77 | IKBKB (0.51) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29012217 | 0.76 | CHEK1 (0.42) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12921997 | 0.76 | GRM2 (0.47) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8847412 | 0.75 | CHEK1 (0.39) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12948558 | 0.75 | CHEK1 (0.39) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8847403 | 0.74 | CHEK1 (0.42) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8846528 | 0.73 | CHEK1 (0.42) | IKBKBCHUKCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | claimed |
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | disclosed |