Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.59 |
| ▸ | TPH2 | Q8IWU9 | 11/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | CCKAR | P32238 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27876229 | 0.99 | TPH1 (0.58) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL27726665 | 0.92 | TPH1 (0.63) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL870447 | 0.92 | TPH1 (0.63) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL27892907 | 0.92 | TPH1 (0.62) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL870414 | 0.92 | TPH1 (0.65) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL870692 | 0.92 | TPH1 (0.62) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL870534 | 0.91 | TPH1 (0.65) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL27726676 | 0.88 | TPH1 (0.46) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL27892947 | 0.88 | TPH1 (0.45) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL4407226 | 0.85 | TPH1 (0.57) | TPH1TPH2ADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101351451-A | Polycyclic amino acid derivatives and methods of use thereof | LEXICON GENETICS INC (US) | 2009-01-21 | — | — | CN | claimed |
| CN-101351451-B | Polycyclic amino acid derivatives and methods of use thereof | LEXICON PHARMACEUTICALS INC | 2013-02-20 | — | — | CN | disclosed |
| CN-102711757-A | Methods and assays for treating irritable bowel syndrome | LEXICON PHARMACEUTICALS INC | 2012-10-03 | — | — | CN | disclosed |
| CN-101969952-A | Compositions comprising tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS INC | 2011-02-09 | — | — | CN | disclosed |
| CN-101815534-A | methods and compositions for treating pulmonary hypertension and related diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-08-25 | — | — | CN | disclosed |
| CN-101801385-A | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein | LEXICON PHARMACEUTICALS INC | 2010-08-11 | — | — | CN | disclosed |
| CN-101784269-A | methods of treating serotonin-mediated diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-07-21 | — | — | CN | disclosed |
| CN-101351451-A | Polycyclic amino acid derivatives and methods of use thereof | LEXICON GENETICS INC (US) | 2009-01-21 | — | — | CN | disclosed |