Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28796445 | 0.87 | BACE1 (0.42) | HDAC1KDM4EAPOBEC3AGFERAPOBEC3G | |
| SCHEMBL27879328 | 0.87 | ADORA1 (0.43) | HDAC1KDM4EAPOBEC3AGFERAPOBEC3G | |
| SCHEMBL28794193 | 0.86 | HDAC1 (0.41) | HDAC1KDM4EAPOBEC3AGFERAPOBEC3G | |
| SCHEMBL27850673 | 0.80 | CA12 (0.45) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL27769336 | 0.78 | TDP1 (0.44) | HDAC1KDM4EHDAC3HDAC2LMNA | |
| SCHEMBL27769325 | 0.78 | TDP1 (0.44) | KDM4ELMNATSHRGAAMAPK1 | |
| SCHEMBL5421934 | 0.75 | ACHE (0.54) | KDM4ENPSR1LMNATSHRGAA | |
| SCHEMBL27748176 | 0.74 | PTGS1 (0.62) | HDAC1KDM4EAPOBEC3AGFERAPOBEC3G | |
| SCHEMBL31051459 | 0.74 | NPSR1 (0.54) | HDAC1KDM4EAPOBEC3AGFERAPOBEC3G | |
| SCHEMBL14571741 | 0.73 | MAPT (0.58) | HDAC1KDM4EAPOBEC3AGFERAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214464-B | Tetrazole-substituted arylamides and application of tetrazole-substituted arylamides using as p2x3 and p2x2/3 receptor antagonists | HOFFMANN LA ROCHE | 2015-02-18 | — | — | CN | disclosed |
| CN-103159692-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-06-19 | — | — | CN | disclosed |
| CN-101479250-B | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-101479250-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |