Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.66 |
| ▸ | CCR1 | P32246 | 7/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28777146 | 0.92 | ELANE (0.67) | ELANECCR1NOTUMMEN1KMT2A | |
| SCHEMBL2273635 | 0.91 | ELANE (0.81) | ELANECCR1NOTUMMEN1KMT2A | |
| SCHEMBL985971 | 0.89 | ELANE (0.83) | ELANENOTUMMEN1KMT2APOLB | |
| SCHEMBL560968 | 0.85 | ELANE (0.63) | ELANENOTUMMEN1KMT2APOLB | |
| SCHEMBL4452188 | 0.83 | KMT2A (0.51) | ELANECCR1NOTUMMEN1KMT2A | |
| SCHEMBL3156451 | 0.83 | ELANE (0.61) | ELANECCR1NOTUMMEN1KMT2A | |
| SCHEMBL2277940 | 0.82 | ELANE (0.82) | ELANECCR1NOTUMMEN1KMT2A | |
| SCHEMBL17378390 | 0.82 | ELANE (0.83) | ELANEMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL18879434 | 0.81 | ELANE (0.82) | ELANENOTUMMEN1KMT2ACYP3A4 | |
| SCHEMBL27888247 | 0.80 | ELANE (0.80) | ELANECCR1NOTUMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490033-A | 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | CN | disclosed |