Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.63 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | GSR | P00390 | 2/20 | 0.40 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.39 |
| ▸ | MICA | Q29983 | 1/20 | 0.39 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17378375 | 0.92 | ELANE (0.63) | ELANENOTUMATMPOLBMEN1 | |
| SCHEMBL18880052 | 0.91 | ELANE (0.62) | ELANENOTUMATMPOLBMEN1 | |
| SCHEMBL18880123 | 0.89 | ELANE (0.60) | ELANENOTUMATMMEN1KMT2A | |
| SCHEMBL18876707 | 0.86 | NOTUM (0.49) | ELANENOTUMPOLBMEN1KMT2A | |
| SCHEMBL28777146 | 0.86 | ELANE (0.67) | ELANENOTUMPOLBMEN1KMT2A | |
| SCHEMBL561598 | 0.85 | ELANE (0.67) | ELANENOTUMATMHTR2AHTR2C | |
| SCHEMBL27749321 | 0.85 | ELANE (0.66) | ELANENOTUMPOLBMEN1KMT2A | |
| SCHEMBL561287 | 0.83 | ELANE (0.65) | ELANENOTUMATMMEN1KMT2A | |
| SCHEMBL985971 | 0.83 | ELANE (0.83) | ELANENOTUMPOLBMEN1KMT2A | |
| SCHEMBL31490428 | 0.82 | ELANE (0.67) | ELANEHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501784-B2 | 2-pyridone derivatives as neutrophil elastase inhibitors and their use | ASTRAZENECA AB (SE) | 2013-08-06 | — | — | US | claimed |
| EP-1663973-B3 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2019-09-25 | — | — | EP | disclosed |
| EP-3107911-B1 | SUBSTITUTED PYRIDONES AND PYRAZINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2018-10-31 | — | — | EP | disclosed |
| US-20170144998-A1 | ELASTASE INHIBITORS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH | 2017-05-25 | — | — | US | disclosed |
| US-20170144998-A1 | ELASTASE INHIBITORS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH | 2017-05-25 | — | — | US | disclosed |
| EP-3107911-A1 | SUBSTITUTED PYRIDONES AND PYRAZINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015200349-A2 | ELASTASE INHIBITORS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-12-30 | — | — | WO | disclosed |
| US-9221807-B2 | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-12-29 | — | — | US | disclosed |
| US-9221807-B2 | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-12-29 | — | — | US | disclosed |
| US-9221807-B2 | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-12-29 | — | — | US | disclosed |
| US-20100216843-A1 | NOVEL SALT 628 | ASTRAZENECA R&D | 2010-08-26 | — | — | US | disclosed |
| US-20090131483-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | HANSEN PETER | 2009-05-21 | — | — | US | disclosed |
| CN-101142189-A | 2-pyridine derivatives as inhibitors of neutrophile elastase | ASTRAZENECA AB (SE) | 2008-03-12 | — | — | CN | disclosed |
| EP-1861370-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | AstraZeneca AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2007107706-A2 | DIMERS OF HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF COPD | ARGENTA DISCOVERY LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |
| US-20070203129-A1 | 2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use | ASTRAZENECA AB (SE) | 2007-08-30 | — | — | US | disclosed |
| CN-1882542-A | 2-pyridone derivatives as inhibitors of neutrophil elastase and uses thereof | ASTRAZENECA AB (SE) | 2006-12-20 | — | — | CN | disclosed |
| WO-2006098683-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-09-21 | — | — | WO | disclosed |
| EP-1663973-A1 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026123-A1 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203129-A1 | 2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use | SERPINB1, ELANE, SERPINE1 | ELANE 2/4885NOTUM 3343/4885ATM 2639/4885 |
| US-20100216843-A1 | NOVEL SALT 628 | REN, SCN8A, SLC38A7 | ELANE 2508/4885NOTUM 1275/4885ATM 2957/4885 |
| US-20090131483-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | SERPINB1, ELANE, MPO | ELANE 2/4885NOTUM 2923/4885ATM 2954/4885 |
| US-20170144998-A1 | ELASTASE INHIBITORS | SERPINB1, ELANE, CELA1 | ELANE 2/4885NOTUM 551/4885ATM 2579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.