Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 5/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1576330 | 0.74 | HPGD (0.51) | SRD5A1KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL27946472 | 0.73 | AVPR1A (0.39) | SRD5A1NOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL7257921 | 0.73 | NOTUM (0.46) | SRD5A1NOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL2616322 | 0.73 | MEN1 (0.58) | SRD5A1NOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL14473207 | 0.73 | NOTUM (0.46) | SRD5A1NOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL13993091 | 0.72 | NOTUM (0.46) | SRD5A1NOTUMHDAC1HDAC6HDAC8 | |
| SCHEMBL4524596 | 0.71 | SMN1; SMN2 (0.46) | NOTUMKMT2APOLBSMN1; SMN2MEN1 | |
| SCHEMBL3948225 | 0.71 | HDAC1 (0.61) | NOTUMHDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL5547425 | 0.71 | HDAC1 (0.61) | NOTUMHDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL9843864 | 0.71 | NOTUM (0.56) | SRD5A1NOTUMHDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101365686-A | Heterocyclic derivatives as modulators of ion channels | VERTEX PHARMA (US) | 2009-02-11 | — | — | CN | disclosed |