Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.56 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9442261 | 0.91 | NOTUM (0.59) | NOTUMHSD17B3HDAC1HDAC6HDAC8 | |
| SCHEMBL9045039 | 0.83 | NOTUM (0.61) | NOTUMHSD17B3HDAC1HDAC6HDAC8 | |
| SCHEMBL11722262 | 0.79 | NOTUM (0.49) | NOTUMHSD17B3HDAC1HDAC6HDAC8 | |
| SCHEMBL16817949 | 0.77 | NOTUM (0.56) | NOTUMHSD17B3HDAC1HDAC6HDAC8 | |
| SCHEMBL29875631 | 0.74 | NOTUM (0.61) | NOTUMHSD17B3SCN9A | |
| SCHEMBL3526981 | 0.74 | NOTUM (0.61) | NOTUMHSD17B3SCN9A | |
| SCHEMBL2061464 | 0.73 | ATAD2 (0.47) | NOTUMHSD17B3AVPR2AVPR1A | |
| SCHEMBL5009163 | 0.72 | NOTUM (1.00) | NOTUMHSD17B3AVPR1A | |
| SCHEMBL10353391 | 0.71 | LMNA (0.57) | NOTUMHSD17B3NCOR2 | |
| SCHEMBL27750511 | 0.71 | SRD5A1 (0.46) | NOTUMHDAC1HDAC6HDAC8AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409435-A1 | Heteroaryl piperazine antipsychotic agents | PFIZER INC. (US) | 1991-01-23 | — | — | EP | disclosed |