Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 14/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.61 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731507 | 0.99 | TOP1 (0.74) | TOP1MEN1KMT2AGLAGAA | |
| SCHEMBL27699980 | 0.90 | TOP1 (0.77) | TOP1MEN1KMT2AGLACYP3A4 | |
| SCHEMBL27731508 | 0.89 | TOP1 (0.78) | TOP1MEN1KMT2AGLACYP3A4 | |
| Ammonia Solution, Strong SCHEMBL27699979 | 0.89 | TOP1 (0.76) | TOP1MEN1KMT2AGLACYP3A4 | |
| SCHEMBL4577454 | 0.88 | TOP1 (0.70) | TOP1MEN1KMT2A | |
| SCHEMBL24951832 | 0.87 | MEN1 (0.80) | TOP1MEN1KMT2AGLAGAA | |
| SCHEMBL17073896 | 0.87 | MEN1 (0.80) | TOP1MEN1KMT2AGLAGAA | |
| SCHEMBL6831175 | 0.87 | MEN1 (0.80) | TOP1MEN1KMT2AGLAGAA | |
| SCHEMBL4449734 | 0.87 | TOP1 (0.77) | TOP1MEN1KMT2AGLAGAA | |
| SCHEMBL27752129 | 0.87 | TOP1 (0.68) | TOP1MEN1KMT2AGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101376658-A | 7-position cycloalkyl substituted camptothecine derivative, synthetic method and use thereof | USTC UNIV SCIENCE TECH CN (CN) | 2009-03-04 | — | — | CN | claimed |
| CN-101376658-A | 7-position cycloalkyl substituted camptothecine derivative, synthetic method and use thereof | USTC UNIV SCIENCE TECH CN (CN) | 2009-03-04 | — | — | CN | disclosed |