Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | HBB | P68871 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL27699979 | 0.99 | TOP1 (0.76) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27731508 | 0.99 | TOP1 (0.78) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27752128 | 0.90 | TOP1 (0.74) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4449734 | 0.89 | TOP1 (0.77) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27731507 | 0.89 | TOP1 (0.74) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27547969 | 0.88 | TOP1 (0.73) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5319419 | 0.88 | MEN1 (0.82) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4060789 | 0.88 | MEN1 (0.82) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20471997 | 0.88 | MEN1 (0.82) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2022729 | 0.87 | TOP1 (0.71) | TOP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101376658-A | 7-position cycloalkyl substituted camptothecine derivative, synthetic method and use thereof | USTC UNIV SCIENCE TECH CN (CN) | 2009-03-04 | — | — | CN | claimed |
| CN-101376658-A | 7-position cycloalkyl substituted camptothecine derivative, synthetic method and use thereof | USTC UNIV SCIENCE TECH CN (CN) | 2009-03-04 | — | — | CN | disclosed |
| CN-101024644-A | Novel anti-tumor compound and its preparing method | GENG YAN (CN) | 2007-08-29 | — | — | CN | disclosed |