Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Ammonia Solution, Strong. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.63 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.63 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.59 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.59 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.59 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.59 |
| ▸ | GALR3 | O60755 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL468696 | 1.00 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Iodide SCHEMBL27664579 | 0.98 | CHRM5 (0.61) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL30183040 | 0.98 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL180003 | 0.98 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL15954 | 0.98 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Iodide SCHEMBL27664578 | 0.96 | CHRM5 (0.59) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Iodide SCHEMBL723953 | 0.96 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL28351837 | 0.96 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Bromide SCHEMBL366432 | 0.96 | CHRM1 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL31575073 | 0.96 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101353392-A | Preparation method of high molecular weight instant cationic polyacrylamide | DINGYANG ZHU (CN) | 2009-01-28 | — | — | CN | claimed |
| CN-101935375-B | Preparation method of acrylamide/2-[(acryloyloxy)ethyl]trimethylammonium chloride copolymer | UNIV TAIYUAN TECHNOLOGY | 2012-03-14 | — | — | CN | disclosed |
| CN-101935375-A | Preparation method of acrylamide/2-[(acryloyloxy)ethyl]trimethylammonium chloride copolymer | UNIV TAIYUAN TECHNOLOGY | 2011-01-05 | — | — | CN | disclosed |
| CN-101353392-B | Preparation of high molecular weight instant cation polyacrylamide | DINGYANG ZHU | 2010-10-13 | — | — | CN | disclosed |
| CN-101353392-A | Preparation method of high molecular weight instant cationic polyacrylamide | DINGYANG ZHU (CN) | 2009-01-28 | — | — | CN | disclosed |