Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27930782 | 0.85 | HTT (0.45) | HTTNOTUMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27752252 | 0.81 | MRGPRX4 (0.47) | SMN1; SMN2GAAUSP2HPGDMRGPRX4 | |
| SCHEMBL12682532 | 0.79 | HTT (0.49) | HTTNOS3NOS1NOS2POLQ | |
| SCHEMBL13034130 | 0.79 | GAA (0.49) | NOTUMSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL14446886 | 0.78 | MAOB (0.60) | HTTPOLQGAAMAOAMAOB | |
| SCHEMBL10283739 | 0.77 | NOS3 (0.50) | HTTNOS3NOS1NOS2POLQ | |
| SCHEMBL671079 | 0.77 | POLQ (0.45) | HTTSMN1; SMN2MEN1KMT2ANOS3 | |
| SCHEMBL13034127 | 0.76 | GAA (0.47) | SMN1; SMN2GAAUSP2HPGDMAOA | |
| SCHEMBL270573 | 0.76 | HTT (0.44) | HTTNOS3NOS1NOS2POLQ | |
| SCHEMBL32682718 | 0.76 | DDR1 (0.45) | HTTNOS3NOS1NOS2POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101374841-A | Spiroimidazole Derivatives as PPAR Modulators | IRM LLC (BM) | 2009-02-25 | — | — | CN | disclosed |