Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GALR3 | O60755 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4578900 | 0.85 | HDAC1 (0.70) | HDAC1RAB9AHDAC3HIF1AEPAS1 | |
| SCHEMBL4579730 | 0.85 | HDAC1 (0.79) | HDAC1RAB9AHDAC3HIF1AEPAS1 | |
| SCHEMBL4579920 | 0.85 | HDAC1 (0.67) | HDAC1RAB9AHDAC3HIF1AEPAS1 | |
| SCHEMBL14155855 | 0.84 | RAB9A (0.60) | HDAC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL4580174 | 0.83 | HDAC1 (0.64) | HDAC1HDAC3HIF1AEPAS1KCNH2 | |
| SCHEMBL4578211 | 0.83 | HDAC2 (0.62) | HDAC1RAB9AHDAC3HIF1AEPAS1 | |
| SCHEMBL4579854 | 0.82 | HDAC1 (0.57) | HDAC1RAB9AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL4578653 | 0.82 | HDAC1 (0.70) | HDAC1RAB9AHDAC3HIF1AEPAS1 | |
| SCHEMBL4578865 | 0.82 | NPC1 (0.68) | HDAC1RAB9AMAPK1LMNAMAPT | |
| SCHEMBL4578145 | 0.80 | HDAC1 (0.64) | HDAC1HDAC3KCNH2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466670-B | Inhibitors of histone deacetylase | METHYLGENE INC | 2013-04-17 | — | — | CN | claimed |
| CN-101466670-B | Inhibitors of histone deacetylase | METHYLGENE INC | 2013-04-17 | — | — | CN | disclosed |
| CN-101466670-A | Benzamide derivatives as inhibitors of histone deacetylase | METHYLGENE INC (CA) | 2009-06-24 | — | — | CN | disclosed |