SCHEMBL27756459

SCHEMBL27756459

O=C(O)c1ccc2oc(NC(F)(F)F)nc2c1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 11/20 0.49
HDAC3 O15379 3/20 0.44
HDAC1 Q13547 3/20 0.44
HDAC8 Q9BY41 3/20 0.44
HDAC2 Q92769 2/20 0.43
KCNH2 Q12809 2/20 0.43
MEN1 O00255 1/20 0.43
GAA P10253 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.41
MBOAT4 Q96T53 1/20 0.41
POLB P06746 1/20 0.41
NPC1 O15118 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 1/20 0.41
SCD O00767 1/20 0.40
SSTR1 P30872 1/20 0.40
SSTR5 P35346 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31430456 0.79 HDAC6 (0.54) HDAC6HDAC3HDAC1HDAC8KCNH2
SCHEMBL2931110 0.77 HDAC6 (0.53) HDAC6KCNH2MEN1GAAKMT2A
SCHEMBL31430548 0.77 HDAC6 (0.62) HDAC6HDAC3HDAC1HDAC8KCNH2
SCHEMBL31430624 0.75 LCK (0.57) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL12885864 0.75 HDAC6 (0.44) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL23698048 0.74 MGLL (0.52) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL6790090 0.73 TDP1 (0.47) HDAC6MEN1GAAKMT2ASMN1; SMN2
SCHEMBL9237045 0.73 HDAC6 (0.49) HDAC6HDAC3HDAC1HDAC8KCNH2
SCHEMBL21066322 0.73 HDAC6 (0.52) HDAC6HDAC3HDAC1HDAC8KCNH2
SCHEMBL31430603 0.73 HDAC6 (0.58) HDAC6HDAC3HDAC1HDAC8KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101379060-A Benzoxazole-based derivatives as Aurora kinase inhibitors, compositions, and methods of use TRANSTECH PHARMA INC (US) 2009-03-04 CN disclosed