Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | BRAF | P15056 | 13/20 | 0.44 |
| ▸ | EGFR | P00533 | 10/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23111995 | 0.82 | KIT (0.67) | KITBRAFEGFRHTTRAF1 | |
| SCHEMBL18298084 | 0.80 | KIT (0.71) | KITBRAFEGFRHTTMAPK1 | |
| SCHEMBL21611712 | 0.77 | KIT (0.65) | KITBRAFHTT | |
| SCHEMBL29561783 | 0.77 | KIT (0.65) | KITBRAFHTT | |
| SCHEMBL27651419 | 0.76 | POLQ (0.40) | — | |
| SCHEMBL18298086 | 0.75 | KIT (0.64) | KITBRAFEGFRHTT | |
| SCHEMBL27651402 | 0.75 | ABL1 (0.69) | KITBRAF | |
| SCHEMBL27651406 | 0.75 | ABL1 (0.69) | KITBRAF | |
| Hydrochloric Acid SCHEMBL27651417 | 0.75 | ABL1 (0.68) | KITBRAF | |
| SCHEMBL5498213 | 0.74 | KIT (0.61) | KITBRAFHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490053-B | Monocyclic Heteroaryl Compounds | ARIAD PHARMA INC | 2013-09-11 | — | — | CN | disclosed |
| CN-101490053-A | Monocyclic Heteroaryl Compounds | ARIAD PHARMA INC (US) | 2009-07-22 | — | — | CN | disclosed |