Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.57 |
| ▸ | PLK3 | Q9H4B4 | 17/20 | 0.57 |
| ▸ | PLK2 | Q9NYY3 | 17/20 | 0.57 |
| ▸ | BRD4 | O60885 | 3/20 | 0.56 |
| ▸ | TAF1 | P21675 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27757436 | 1.00 | PLK1 (0.57) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376029 | 0.92 | PLK1 (0.54) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL13261134 | 0.92 | PLK1 (0.54) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL27778420 | 0.90 | PLK1 (0.59) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL27778422 | 0.90 | PLK1 (0.59) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL3785572 | 0.87 | PLK1 (0.55) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL3785568 | 0.87 | PLK1 (0.55) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376242 | 0.85 | BRD4 (0.56) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL25785686 | 0.85 | PLK1 (0.67) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL375836 | 0.83 | PLK1 (0.56) | PLK1PLK3PLK2BRD4TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541800-A | Pteridine derivatives as polo-like kinase inhibitors useful in the treatment of cancer | CHROMA THERAPEUTICS LTD (GB) | 2009-09-23 | — | — | CN | disclosed |