Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.56 |
| ▸ | TAF1 | P21675 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 18/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 17/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 16/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | NEK4 | P51957 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.49 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.49 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.49 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376091 | 0.90 | PLK1 (0.61) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL3785572 | 0.88 | PLK1 (0.55) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL3785568 | 0.88 | PLK1 (0.55) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL27778422 | 0.87 | PLK1 (0.59) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL27778420 | 0.87 | PLK1 (0.59) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL376761 | 0.86 | BRD4 (0.62) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL27757440 | 0.85 | PLK1 (0.57) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL27757436 | 0.85 | PLK1 (0.57) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL25785686 | 0.82 | PLK1 (0.67) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL375836 | 0.81 | PLK1 (0.56) | BRD4TAF1PLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |