Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262 | 0.81 | ALDH1A1 (0.62) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9823358 | 0.81 | ALDH1A1 (0.62) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL1331989 | 0.81 | ALDH1A1 (0.62) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL27947493 | 0.79 | ALDH1A1 (0.41) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL19958915 | 0.79 | ALDH1A1 (0.45) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL5002228 | 0.78 | NPSR1 (0.45) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL30076441 | 0.78 | ALDH1A1 (0.59) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL9751764 | 0.78 | ALDH1A1 (0.59) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL28824460 | 0.78 | ALDH1A1 (0.59) | NPSR1GLO1ALDH1A1LMNAHSD17B10 | |
| Ammonia Solution, Strong SCHEMBL12803984 | 0.78 | ALDH1A1 (0.59) | NPSR1GLO1ALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101395157-A | Pyrrazole derivatives as sigma receptors antagonists | ESTEVE LABOR DR (ES) | 2009-03-25 | — | — | CN | claimed |
| CN-109310672-A | Purposes of the sigma-receptor ligand in cancer | 埃斯特韦制药有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-106999473-A | Purposes of the sigma-receptor part in osteoarthritis | 埃斯蒂文博士实验室股份有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-102741248-B | New (heterocycle/condense piperidines)-(piperazinyl)-1-alkane ketone or (heterocycle/condense tetramethyleneimine)-(piperazinyl)-1-alkane ketone derivatives and the purposes as p75 inhibitor thereof | SAI NUOFEI (FR) | 2016-01-20 | — | — | CN | disclosed |
| CN-102741248-A | Novel (heterocycle/condensed piperidine)-(piperazinyl)-1-alcanone or (heterocycle/condensed pyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors | SANOFI AVENTIS | 2012-10-17 | — | — | CN | disclosed |
| CN-102656162-A | Novel (heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors | SANOFI SA | 2012-09-05 | — | — | CN | disclosed |
| CN-102414198-A | Synthesis of 3- { [ (2R) -1-methylpyrrolidin-2-yl ] methyl } -5- [2- (phenylsulfonyl) ethyl ] -1H-indole | ITALIANA SINT SPA | 2012-04-11 | — | — | CN | disclosed |
| CN-101395157-A | Pyrrazole derivatives as sigma receptors antagonists | ESTEVE LABOR DR (ES) | 2009-03-25 | — | — | CN | disclosed |