Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 11/20 | 0.55 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851272 | 0.89 | GLS (0.55) | GLSKDM4ABRD4CREBBPAKT1 | |
| SCHEMBL30192965 | 0.89 | GLS (0.55) | GLSKDM4ABRD4CREBBPAKT1 | |
| SCHEMBL21455404 | 0.87 | GLS (0.54) | GLSKDM4ABRD4CREBBPNAMPT | |
| SCHEMBL15656811 | 0.86 | GLS (0.53) | GLSKDM4ABRD4CREBBPNAMPT | |
| SCHEMBL5729298 | 0.85 | GLS (0.54) | GLSKDM4ABRD4CREBBPCA12 | |
| SCHEMBL16181822 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPNAMPT | |
| SCHEMBL30069429 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPNAMPT | |
| SCHEMBL1165088 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPNAMPT | |
| SCHEMBL13981921 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPNAMPT | |
| SCHEMBL8342682 | 0.84 | GLS (0.55) | GLSKDM4ABRD4CREBBPNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101691370-A | Triazolo[4,5-d] pyrimidine derivatives and their use as purinergic receptor antagonists | VERNALIS RES LTD | 2010-04-07 | — | — | CN | disclosed |
| CN-101531631-A | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP (US) | 2009-09-16 | — | — | CN | disclosed |