Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Phenoxazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.94 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenoxazine SCHEMBL25275195 | 1.00 | ALOX5 (0.94) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL28844098 | 0.97 | ALOX5 (1.00) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL6310178 | 0.97 | ALOX5 (1.00) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL29355714 | 0.97 | ALOX5 (1.00) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL7862 | 0.97 | ALOX5 (1.00) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL29944236 | 0.94 | ALOX5 (0.94) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL3112369 | 0.94 | ALOX5 (0.94) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL5808288 | 0.94 | ALOX5 (0.94) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL20840431 | 0.94 | ALOX5 (0.94) | ALOX5GAANPSR1DHODHMEN1 | |
| Phenoxazine SCHEMBL31267446 | 0.94 | ALOX5 (0.94) | ALOX5GAANPSR1DHODHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535324-A | Organic iridium compositions and their use in electronic devices | GEN ELECTRIC (US) | 2009-09-16 | — | — | CN | disclosed |