Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 12/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.44 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275487 | 0.91 | FGFR1 (0.55) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL27739574 | 0.90 | FGFR1 (0.57) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL27739573 | 0.88 | FLT3 (0.57) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL276867 | 0.87 | FGFR1 (0.43) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL59832 | 0.84 | ACVRL1 (0.50) | FGFR1FLT3MAPK9PRKCDBTK | |
| SCHEMBL275149 | 0.81 | FGFR1 (0.69) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL327927 | 0.79 | FGFR1 (0.58) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL276626 | 0.79 | FLT3 (0.55) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL276751 | 0.79 | FGFR1 (0.70) | FGFR1FGFR3FLT3MAPK9RPS6KA3 | |
| SCHEMBL276123 | 0.78 | FLT3 (0.55) | FGFR1FGFR3FLT3MAPK9RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101365454-A | Substituted 4-amino-pyrrolotriazine derivatives for the treatment of hyperproliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-02-11 | — | — | CN | claimed |