Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | CLPP | Q16740 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586168 | 0.85 | GRM5 (0.47) | GRM5CLPPRAB9AALDH1A1LMNA | |
| SCHEMBL3586170 | 0.85 | GRM5 (0.47) | GRM5CLPPRAB9AALDH1A1LMNA | |
| SCHEMBL3584731 | 0.72 | GRM5 (0.68) | GRM5CLPPRAB9AALDH1A1LMNA | |
| SCHEMBL3584728 | 0.72 | GRM5 (0.68) | GRM5CLPPRAB9AALDH1A1LMNA | |
| SCHEMBL3585860 | 0.71 | GRM5 (0.58) | GRM5CLPPRAB9ATSHRMEN1 | |
| SCHEMBL3585856 | 0.71 | GRM5 (0.58) | GRM5CLPPRAB9ATSHRMEN1 | |
| SCHEMBL3585711 | 0.70 | GRM5 (0.57) | GRM5CLPPRAB9AALDH1A1LMNA | |
| SCHEMBL30794892 | 0.70 | GRM5 (0.57) | GRM5CLPPRAB9AALDH1A1LMNA | |
| SCHEMBL3585701 | 0.70 | GRM5 (0.57) | GRM5CLPPRAB9AALDH1A1LMNA | |
| SCHEMBL3586318 | 0.70 | GRM5 (0.56) | GRM5CLPPRAB9AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101558065-A | Oxazole derivatives as positive allosteric modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA (CH) | 2009-10-14 | — | — | CN | disclosed |