Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946291 | 1.00 | MAPT (0.50) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8946294 | 1.00 | MAPT (0.50) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8946299 | 0.82 | KDM4E (0.55) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8946297 | 0.82 | KDM4E (0.55) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8946652 | 0.82 | MAPT (0.55) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8946647 | 0.82 | MAPT (0.55) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8946301 | 0.82 | KDM4E (0.55) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8946640 | 0.82 | MAPT (0.55) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL10061178 | 0.81 | AURKA (0.46) | AURKAAURKBNLRP3 | |
| SCHEMBL8946492 | 0.78 | KDM4E (0.55) | MAPTKDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | claimed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | claimed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | claimed |
| EP-2079691-B1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | UNIV DUESSELDORF H HEINE (DE) | 2013-08-14 | — | — | EP | disclosed |
| US-8133913-B2 | Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids | Heinrich-Heine Universitat Dusseldof (DE) | 2012-03-13 | — | — | US | disclosed |
| US-20110207147-A1 | Compositions and Methods for Modification of Biomolecules | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-08-25 | — | — | US | disclosed |
| US-7829641-B2 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP (US) | 2010-11-09 | — | — | US | disclosed |
| US-20100056599-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | HEINRICH-HEINE UNIVERSITAT DUSSELDORF (DE) | 2010-03-04 | — | — | US | disclosed |
| US-20100016526-A1 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP | 2010-01-21 | — | — | US | disclosed |
| EP-2079691-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | Heinrich-Heine-Universität Düsseldorf (DE) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008040547-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF (DE) | 2008-04-10 | — | — | WO | disclosed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1992006956-A1 | INDENOINDOLE COMPOUNDS | UNIVERSITY OF BATH (GB) | 1992-04-30 | — | — | WO | disclosed |
| EP-0481708-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1992-04-22 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056599-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | CDK2, CSNK1A1, CDK1 | MAPT 2352/4885KDM4E 2927/4885ALDH1A1 3394/4885 |
| US-20110207147-A1 | Compositions and Methods for Modification of Biomolecules | PTMS, APEX1, ALG1 | MAPT 3984/4885KDM4E 2378/4885ALDH1A1 1302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.