Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KIF11 | P52732 | 19/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946530 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946522 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL28570817 | 0.86 | KIF11 (0.47) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946299 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946297 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946301 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946294 | 0.78 | MAPT (0.50) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946291 | 0.78 | MAPT (0.50) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL277613 | 0.78 | MAPT (0.50) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946647 | 0.78 | MAPT (0.55) | KDM4EALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |