Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 11/20 | 0.39 |
| ▸ | CDK9 | P50750 | 11/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3113957 | 0.91 | GRM5 (0.40) | CCNT1CDK9BTK | |
| SCHEMBL1947642 | 0.81 | PIK3CD (0.39) | AXLMET | |
| SCHEMBL1944325 | 0.81 | MET (0.34) | AXLMETHTTSMN1; SMN2NPSR1 | |
| SCHEMBL3112956 | 0.80 | SMN1; SMN2 (0.44) | CDK9KCNK3AXLMEN1KMT2A | |
| SCHEMBL3104428 | 0.79 | CYP1A2 (0.39) | AXLBTK | |
| SCHEMBL28780214 | 0.78 | BTK (0.42) | AXLBTKMETMEN1HTT | |
| SCHEMBL3103567 | 0.78 | JAK1 (0.37) | AXLBTKMETSMN1; SMN2 | |
| SCHEMBL1944519 | 0.78 | AXL (0.38) | AXLBTKMET | |
| SCHEMBL3108799 | 0.78 | AXL (0.36) | AXLBTKMETKDRMEN1 | |
| SCHEMBL3103511 | 0.77 | AXL (0.40) | AXLMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437820-A | Heterobicyclic pyrazole compounds and methods of use | ARRAY BIOPHARMA INC (US) | 2009-05-20 | — | — | CN | disclosed |