Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ASPH | Q12797 | 3/20 | 0.38 |
| ▸ | RIOX2 | Q8IUF8 | 3/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27839482 | 0.86 | MRGPRX4 (0.50) | PLK1HCAR2NR1H4MRGPRX4KDM4E | |
| SCHEMBL27741392 | 0.80 | MAPT (0.58) | GAAKDM4EALDH1A1HSD17B10PKM | |
| SCHEMBL498151 | 0.77 | CA1 (0.44) | GAAKDM4EALDH1A1HSD17B10ESRRG | |
| SCHEMBL39010 | 0.74 | CA12 (0.57) | ALDH1A1HSD17B10RGS12EGFRLCK | |
| SCHEMBL28126806 | 0.74 | CA12 (0.57) | ALDH1A1HSD17B10RGS12EGFRLCK | |
| SCHEMBL27740964 | 0.74 | NR3C2 (0.36) | HCAR2ALDH1A1ESRRGEGFRLCK | |
| SCHEMBL497871 | 0.74 | NR1H4 (0.49) | PLK1HCAR2NR1H4ALDH1A1HSD17B10 | |
| SCHEMBL27658957 | 0.73 | CA12 (0.55) | ALDH1A1HSD17B10RGS12EGFRLCK | |
| SCHEMBL3873135 | 0.73 | CA12 (0.55) | ALDH1A1HSD17B10RGS12EGFRLCK | |
| SCHEMBL27517848 | 0.73 | CA12 (0.55) | ALDH1A1HSD17B10RGS12EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101448791-B | Fxr agonists | LILLY CO ELI | 2011-11-16 | — | — | CN | disclosed |
| CN-101448791-A | FXR agonists | LILLY CO ELI (US) | 2009-06-03 | — | — | CN | disclosed |
| CN-101448798-A | Compounds and methods for modulating FXR | LILLY CO ELI (US) | 2009-06-03 | — | — | CN | disclosed |