Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776224 | 1.00 | CNR2 (0.42) | CNR2KDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL2777232 | 0.84 | TMEM97 (0.43) | MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2777224 | 0.84 | TMEM97 (0.43) | MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2777229 | 0.84 | TMEM97 (0.43) | MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8662878 | 0.79 | CNR2 (0.50) | CNR2KDM4ETLR8MAPK1ALDH1A1 | |
| SCHEMBL2775582 | 0.78 | MEN1 (0.53) | MAPTHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL2775584 | 0.78 | MEN1 (0.53) | MAPTHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL2775579 | 0.78 | MEN1 (0.53) | MAPTHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL25316072 | 0.78 | CNR2 (0.56) | CNR2KDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL8862370 | 0.78 | CNR2 (0.56) | CNR2KDM4EMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906541-B2 | Process to prepare new substituted 1H-benzo[d]imidazol-2(3H)-ones, new intermediates and their use as BACE 1 inhibitors | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2011-03-15 | — | — | US | claimed |
| WO-2010052670-A1 | PROCESS TO PREPARE NEW SUBSTITUTED 1H-BENZO [d] IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-14 | — | — | WO | claimed |
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-13 | — | — | US | claimed |
| US-7906541-B2 | Process to prepare new substituted 1H-benzo[d]imidazol-2(3H)-ones, new intermediates and their use as BACE 1 inhibitors | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2011-03-15 | — | — | US | disclosed |
| WO-2010052670-A1 | PROCESS TO PREPARE NEW SUBSTITUTED 1H-BENZO [d] IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-13 | — | — | US | disclosed |
| EP-2184276-A1 | Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors | UNIVERSITE PAUL CEZANNE AIX-MARSEILLE III (FR) | 2010-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | BACE1, BACE2, PSEN1 | CNR2 3287/4885KDM4E 3435/4885MAPT 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.